Antimicrobial resistance (AMR) of bacteria has become crisis of global public health security, World Health Organization (WHO) requires all countries in the world to take positive action and take systematic measures to curb bacterial resistance. In this paper, the occurrence process, risk factors and control strategies of antimicro-bial-resistant bacteria are elaborated, which indicates that the occurrence and spread of AMR are closely related to the use of antimicrobial agents and infection control, suggests that the control of AMR must carry out the clinical application management of antimicrobial agents and infection control at the same time, success can be achieved through coordination with each other.