Eikenella corrodens(E. corrodens) is a kind of bacteria colonized on the surface of human mucosa, which often distributs in the oral cavity and upper respiratory tract, and seldom causes disease. When the immunity of human body is low, E. corrodens may cause infection. It was reported in the literatures that E. corrodens usually causes cervical abscess, liver abscess and abdominal cavity infection, while thoracic and pulmonary infections are rare. This article reports that a case of empyema due to infection of E. corrodens was improved after treated with medical thoracoscopy, surgical thoracoscopy and systemic anti-infection, so as to improve the clinical understanding of empyema caused by E. corrodens, achieve early diagnosis and treatment.