In recent years, the role of intestinal flora in diseases has attracted more and more attention, and its important role in resisting Candida albicans infection has also been widely recognized. This article explores the role and mechanism of intestinal microbes against Candida albicans invasive infection from three aspects of intestinal probiotics, commensal bacteria, and short-chain fatty acids of intestinal microbial metabolites, so as to provide ideas and theoretical basis for clinical treatment.