On December 7, 2022, the Notice on Further Optimizing the Implementation of COVID- 19 Prevention and Control Measures (referred to as "Ten new guidelines") proposed that all levels of medical institutions should ensure normal medical services and provide medical convenience for special patients. As the main force of medical treatment and control of epidemic spread, health care workers (HCWs) are at high risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. After HCWs are infected with SARS-CoV-2, correct treatment and isolation measures can fundamentally ensure their healthy and safety, which is also a strong guarantee for the treatment of patients. After soliciting relevant experts' opinions, according to current epidemic situation and virus mutation of COVID-19, on the basis of referring national documents, guidelines and authoritative literatures, as well as in combination with practical experience in COVID-19 epidemic prevention and control management, the National Healthcare-associated Infection Monitoring and Management Training Center as well as Editorial Board of Chinese Journal of Infection Control proposed suggestions and corresponding specific measures for COVID-19 infection management, home treatment and return to work of HCWs, for the reference of relevant medical institutions and HCWs.