Objective To analyze the risk factors for surgical site infection (SSI) in patients with hepatic hydatidosis. Methods Patients who underwent surgery for hepatic hydatidosis in Qinghai Provincial People's Hospital from January 2017 to December 2020 were selected, according to whether there was SSI, they were divided into infection group and control group. Medical data of patients were analyzed retrospectively, risk factors for SSI in patients with hepatic hydatidosis were analyzed by univariate and multivariate logistic regression analysis. Results A total of 681 patients were included, there were 59 cases of SSI, with an infection rate of 8.66%, including 23 cases of incisional infection, 28 cases of abdominal infection, 6 cases of incisional+abdominal infection and 2 cases of subphrenic infection. A total of 63 strains of pathogens were isolated from infected patients, Gram-negative and Gram-positive bacteria accounted for 63.49% and 34.92% respectively. Pseudomonas aeruginosa, Acinetobacter baumannii and Enterococcus faecalis accounted for 17.46%, 9.53% and 7.94% respectively. Multivariate logistic regression analysis showed that diabetes mellitus, history of surgery for hepatic hydatidosis, post-operative bile leakage, indwelling time of drainage tube ≥15 days, and duration of surgery ≥250 minutes were independent risk factors for SSI in patients with hepatic hydatidosis (all P < 0.05). Conclusion There are multiple risk factors for SSI in patients with hepatic hydatidosis, actively controlling blood glucose during and after surgery, avoiding the recurrence of hepatic hydatidosis as much as possible to reduce the surgery for hepatic hydatidosis, actively preventing post-operative bile leakage, shortenning operation time and reducing the indwelling time of drainage tube can play a positive role in the prevention of SSI.