Objective To understand the disease characteristics and treatment of a pregnant COVID -19 woman who gave birth to triplets, as well as delivery outcome of triplets. Methods Clinical data, diagnosis and treatment process of the first pregnant COVID -19 woman who gave birth to triplets in China, as well as accompany delivery, monitoring methods and outcomes of premature infants were analyzed. Results One woman who was 28-week pregnancy and with 13-hour severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid positive was admitted in a hospital, persistent high fever and dyspnea occurred during disease course. Convalescent plasma (CP) of COVID -19 patient and methylprednisolone were given, condition improved after timely treatment of relevant symptoms. At 32⁺⁵ weeks of gestation, cesarean section was performed due to severe intrahepatic cholestasis in pregnancy (ICP), as well as three chorionic villus and three amniotic cavity (the fetuses were in head, hip and transverse position respectively). Patient was discharged after two consecutive negative test result of SARS-CoV-2 nucleic acid. Each premature infant delivered by caesarean section was individually transported to a single neonatal intensive care unit by the neonatal escort transport team (wearing secondary protective clothing) for isolated treatment. During hospitalization, SARS-CoV-2 nucleic acid and SARS-CoV-2 IgM test were both negative; SARS-CoV-2 IgG test was positive, value gradually decreased. Pregnant woman and three premature infants were treated suc-cessfully and reached the discharge standard. Conclusion Convalescent plasma and methylprednisolone are effective for the treatment of COVID -19 pregnant woman with triplets, timely treatment of anemia, anxiety, insomnia and other related symptoms is helpful for the treatment of pregnant woman with triplets. The progress of ICP in pregnant COVID -19 woman with triplets is fast, and delivery is an effective treatment. Three premature infants by cesarean section of COVOD-19 pregnant woman did not have intrauterine vertical transmission.