Left ventricular assist is now the main surgical treatment strategy for patients with end-stage heart fai-lure, while it improves survival in heart failure patients, it often leads to a number of serious complications. Ventri-cular assist device-specific infection, particularly driveline infection, is a common post-operative complication in ventricular assist patients. Biofilm formation and migration promote the infection spread to deeper tissues such as the pump cavity and blood stream, making subsequent treatment more difficult and even endangering the patient's life. This article reviews the current status of left ventricular assist device driveline infection in terms of epidemiological characteristics, pathogenic mechanisms, diagnosis, as well as prevention and treatment.