Objective To evaluate the quality management status and existing problems of central sterile supply department (CSSD) in China, and provide reference basis for standardizing the management of CSSD as well as prevention and control of healthcare-associated infection (HAI). Methods Literatures on the current status of CSSD quality management in hospitals in various regions of China published on China National Knowledge Infrastructure (CNKI), VIP, Wanfang Data, PubMed, Embase, and Web of Science from January 1, 2012 to January 31, 2022 were searched, literatures were screened and data were extracted by two researchers, Stata14.0 software was adop-ted for Meta-analysis. Results A total of 12 literatures were included, involving 1 435 hospitals, Meta-analysis results showed that according to the subgroup analysis of hospital level, the implementation rate of CSSD centralized management in tertiary hospitals was higher than that in secondary hospitals (81% [95%CI: 65%-97%] vs 61% [95%CI: 30%-92%]); staffing and management of professionals in tertiary hospitals was better than that in se-condary hospitals (86% [95%CI: 76%-97%] vs 74% [95% CI: 59%-89%]); in terms of architectural layout design: the rationality selection of CSSD building location of tertiary hospitals was better than that of secondary hospitals (85% [95%CI: 75%-95%] vs 62% [95%CI: 34%-91%]); in terms of important equipment allocation: the allocation rate of automatic cleaning sterilizer in tertiary hospitals was higher than that in secondary hospitals (79% [95%CI: 64%-94%] vs 48% [95%CI: 20%-76%]); the allocation rate of medical insulation detector in tertiary hospitals was higher than that in secondary hospitals (44% [95%CI: 30%-58%] vs 18% [95%CI: 8%-28%]); allocation rate of pressure steam sterilizer in tertiary hospitals was higher than that in secondary hospitals (86% [95%CI: 68%-105%] vs 80% [95%CI: 67%-94%]); implementation rate of information quality traceability system in tertiary hospitals was higher than that in secondary hospitals (47% [95%CI: 34%-61%] vs 23% [95%CI: 14%-32%]). Conclusion There are some problems in quality management of hospital CSSD in China, including inadequate implementation of centralized management, insufficient allocation and non-standard management of professionals, irrational building layout design, insufficient allocation of equipment and facilities, as well as incomplete adoption of information-based quality traceability system, which exists certain potential safety problems. It is suggested that hospitals should conscientiously implement the requirements of health industry standards, strengthen the scientific management of CSSD, ensure medical quality and patient life safety.