With the normalization of epidemic prevention and control, the use of personal protective equipment (PPE) tends to become more and more common, meanwhile, due to the high incidence of headache associated with PPE (HAPPE), it has gradually become one of the hotspots of many studies. Combined with the recent relevant research, this paper discusses the pathogenesis, related influencing factors and intervention measures of HAPPE, so as to provide reference for the formulation of intervention plan for HAPPE among health care workers.