The invasiveness of endoscopic diagnosis and treatment manipulation as well the openness of cleaning and disinfection manipulation have made endoscopy center a key area for aerosol generation, long term exposure to aerosol by health care workers (HCWs) can cause great harm to health. This paper summarizes the sources, HCWs' exposure risk as well as prevention and control strategies of aerosol in endoscopy center through reviewing domestic and foreign literatures, provides reference for HCWs in endoscopy center to prevents occupational exposure and protect health.