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The role of NF-κB (p50/p65)-mediated pro-inflammatory microRNAs signal transduction in Staphylococcus aureus infection
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1.The First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China;2.Key Laboratory of Exploring, Innovation and Transformation of Traditional Chinese Medicine in Gansu Province, Gansu Traditional Chinese Medicine New Product Creation Engineering Laboratory, Lanzhou 730000, China;3.School of Nursing, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China;4.Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China

Clc Number:

R378.11

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    Abstract:

    NF-κB (p50/p65)-regulated microRNA (miRNA) have been identified and partially characterized currently in Staphylococcus aureus (SA) infection, including miR-125b, miR-193b-5p, miR-128, miR-146a, miR155, bta-miR-223, and miR-30a. Experimental evidence reveals that upregulation of this pro-inflammatory miRNAs family coordinates the expression of pathogenic genes in SA infection, providing new possibilities for explaining the infection mechanism of SA infection, as well as the spread and severity of the disease. This article reviews NF-κB regu- lation of miRNA-mediated signaling pathways, as well as the therapeutic strategies targeting NF-κB and/or pro-inflammatory miRNA signaling involved in the current research fields, providing references for subsequent related research.

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王天明,车莹,崔岩,等. NF-κB(p50/p65)介导的促炎微小RNA信号转导在金黄色葡萄球菌感染中的作用[J].中国感染控制杂志英文版,2023,(10):1260-1265. DOI:10.12138/j. issn.1671-9638.20233482.
Tian-ming WANG, Ying CHE, Yan CUI, et al. The role of NF-κB (p50/p65)-mediated pro-inflammatory microRNAs signal transduction in Staphylococcus aureus infection[J]. Chin J Infect Control, 2023,(10):1260-1265. DOI:10.12138/j. issn.1671-9638.20233482.

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  • Received:October 14,2022
  • Online: April 28,2024

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