Pancreatic tuberculosis is relatively rare, but with a good prognosis. Surgery and anti-tuberculosis drug treatment have good therapeutic effect. However, its clinical symptoms, laboratory tests, and imaging findings lack specificity, making it highly susceptible to misdiagnosis as tumorous lesions, leading to unnecessary surgical resection. This article reports two cases of pancreatic tuberculosis confirmed by surgery and anti-tuberculosis treatment, as well as the diagnosis and treatment processes, aiming to improve the understanding on pancreatic tuberculosis.