Preventing transmission of seasonal respiratory viral infections in the healthcare setting is critical for the safety of healthcare workers and patients. Seasonal respiratory viral infections are caused by viruses that belong to different viral families but share similar characteristics in the transmission mode and clinical presentations. Proper use of infection control strategies for patients, healthcare workers, and visitors with a respiratory viral infection can effectively prevent its transmission in healthcare settings. Besides the COVID -19 vaccine, vaccines against influenza and respiratory syncytial virus also achieved rapid development.