The excessive use and abuse of antimicrobial agents have led to the emergence of multidrug-resistant organism (MDRO). MDRO infection is becoming increasingly severe and difficult to treat, it is urgent to find new drugs for the treatment of MDRO infection. Chinese herbal medicine is a unique natural resource in China, with advantages of low drug resistance, low toxicity and low price, it has good inhibitory effect on MDRD, and can exert inhibitory effect through various mechanisms.This article collects and sorts out relevant literatures at home and abroad, and reviews inhibitory effect and mechanisms of single traditional Chinese medicine, traditional Chinese medicine compound, and traditional Chinese medicine combined with antimicrobial agents on MDRO, so as to provide theoretical basis for the research of drugs against MDRO.