Objective To investigate the length of hospital stay, hospitalization expense and mortality attributable to the occurrence of carbapenem-resistant Enterobacterales (CRE) infection in patients in intensive care unit (ICU). Methods Patients admitted to the ICU in a tertiary first-class hospital from 2017 to 2022 were selected for the study. According to whether CRE infection occurred, patients were divided into infected group and non-infected group. Propensity score matching method was used to conduct a 1:1 match between the infected group and non-infected group. Length of hospital stay, hospitalization expense and mortality of patients after matching were analyzed statistically. A generalized linear model was established to recalculate the odds ratio (OR) of length of hospital stay, hospitalization expense and mortality of patients after matching. Results After propensity score matching, length of hospital stay of patients in the infected group extended by 10.56 days (P < 0.001), hospitalization expense increased by 36 021.02 Yuan (P < 0.001), and mortality increased by 6.70% (P=0.035). The results of the gene-ralized linear model indicated that OR for length of hospital stay, hospitalization expense, and mortality were 1.187(95%CI: 1.013-1.393), 1.134(95%CI: 0.975-1.318), and 1.130(95%CI: 1.049-1.218) respectively for CRE infected patients, compared with non-infected patients, except for hospitalization expense, length of hospital stay and mortality between two groups were statistically significant (both P < 0.05). Conclusion CRE infection in ICU patients will increase the length of hospital stay, economic burden, and mortality of patients. Measures should be taken to prevent and control CRE infection.