With high morbidity and mortality, the treatment of sepsis still remains a worldwide problem. More and more studies believe that intestinal microbiota has an impact on the occurrence, development and evolution of sepsis. On one hand, sepsis leads to disorder of intestinal microbiota, inducing and aggravating terminal organ dysfunction; on the other hand, the activation of intestinal microbiota as well as the reduction of beneficial microorga-nisms and their products can increase the host's susceptibility to sepsis. Refering to the latest literatures and research progress, this article aims to explore the relationship between adult sepsis and intestinal microbiota, as well as intervention measures for the disorder of intestinal microbiota, so as to develop new ideas for the treatment of sepsis.