G-protein-coupled receptors (GPCRs) are a type of superfamily of transmembrane receptors, involved in multiple signaling pathways, and playing an important role in physiological processes such as cell migration and metabolism. T lymphocytes are important immune cells that participate in the inflammatory process and play an important role cellular immunity. To date, multiple GPCRs have been found to be expressed in T lymphocytes and participate in T cell immunomodulatory processes. This paper reviews the role of GPCRs in T lymphocyte immunomodulation.