Healthcare-associated infection (HAI) is a global public health problem that poses a significant socio-economic burden. Hand hygiene is still considered as one of the most effective measures to prevent the spread of pathogens and reduce the incidence of HAI. This paper systematically reviews the latest progress in hand hygiene-related new products, intelligent monitoring technology, and compliance promotion strategies, aiming to provide scientific basis for the management and optimized scheme of hand hygiene in clinical practice in medical institutions in China, ultimately enhance the hand hygiene compliance of healthcare workers, ensure patient safety, and reduce the burden of HAI.