In the global public health field, healthcare-associated infection (HAI) has become one of the important factors affecting patient safety, decreasing medical quality, and increasing medical expense. This paper comprehensively analyzes relevant research in recent years, deeply explores the relationship between the use of different types of drugs and HAI, including antimicrobial agents, immunosuppressants, and proton pump inhibitors, aiming to systematically review the risk factors and pathogenicity of drug-related HAI in hospitalized patients both domestica-lly and internationally, so as to provide theoretical basis for the prevention and control of HAI.