Abstract:

ObjectiveTo evaluate the blocking effect and mechanism of Soybeanderived BowmanBirk inhibitor (BBI) on LPSmediated downregulation for tight junction protein(HT29 cells) in intestinal epithelial cells(IECs).MethodsThe toxic effect of LPS and BBI on HT29 cells was detected by CCK8 Kit. HT29 cells were pretreated by BBI for 6 hours prior to LPS stimulation, the expression of tight junction protein (ZO1 and Occludin), TLR4, and MyDD8 was detected by the quantitative realtime polymerase chain reaction (PCR) and Western Blot; activation of NFκB was measured by Western Blot.ResultsLPS (1 000ng/mL) and BBI (1 000μg/mL) showed no cytotoxicity on HT29 cells. LPS could significantly upregulate the expression of TLR4 in HT29 cells, the upregulation had timedose effect, and could significantly downregulate the expression of tight junction protein, the downregulation effect was directly proportional to the concentration of LPS, could activate NFκB, and had dose effect, effect of LPS on HT29 cells could be significantly inhibited by BBI.ConclusionBy inhibiting the expression of TLR4 and activation of NFκB in IECs induced by LPS, BBI can significantly block the LPSmediated inhibitory effect on tight junction protein in intestinal epithelial cells.

Abstract:

ObjectiveTo understand the drug resistance of Mycobacterium tuberculosis(MTB) and susceptibility of multidrugresistant MTB (MDRMTB) to linezolid in Hebei Province, so as to guiding clinical treatment of MDR tuberculosis.MethodsThe isolated strains and clinical information of patients with tuberculosis in 6 hospitals of 5 cities in Hebei Province between January and December 2016 were collected, susceptibility of MTB to antituberculous drugs isoniazid (INH), rifampicin（RFP）, streptomycin (SM), ethambutol（EMB）, ofloxacin（OFX）, and kanamycin（KM）were detected, 100 strains of MDRMTB were selected by stratified random sampling method, susceptibility to linezolid was detected.ResultsDrug resistance rate and MDR rate of the initially treated cases were 26.6%（200/753）and 13.5%（102/753） respectively, drug resistance rate and MDR rate of the retreatment cases were 59.7%（132/221）and 53.4（118/221）respectively, drug resistance rate and MDR rate of the retreatment cases were both statistically higher than initially treated cases（χ2=83.7，P＜0.01; χ2=93.5，P＜0.01）. Resistance rates of MTB to firstline antituberculous drugs INH, RFP, SM, and EMB were 25.8%, 23.7%, 16.7%, and 7.1% respectively, to secondline antituberculous drugs OFX and KM were 4.7%（37/782）and 4.0%（31/782） respectively；susceptibility of MDRMTB to linezolid was 80.8% (59/73).ConclusionDrug resistance rate and MDR rate of the retreated tuberculosis patients are higher than initially treated patients, linezolid has good in vitro antimicrobial activity against MDRMTB.

Abstract:

ObjectiveTo detect mRNA expression of stimulator of interferon genes (STING）and type I interferons(IFNα and IFNβ) in peripheral blood mononuclear cells(PBMCs) of patients with chronic hepatitis B(CHB), and evaluate its correlation with hepatitis B virus load．Methods88 untreated CHB patients (CHB group) and 74 healthy persons (control group) who performed physical examination were chosen from Renmin Hospital of Wuhan University during the same period between February 2016 and February 2017. Expressions of mRNA of STING, IFNα, and IFNβ were detected by quantitative realtime polymerase chain reaction (PCR)，their relative expression values were obtained by 2ΔΔCT method, results were statistically analyzed.ResultsThe expression of STING, IFNα, and IFNβ mRNA in peripheral blood of CHB patients were 2.95, 3.14, and 2.01 folds of healthy controls respectively, differences were statistically significant( t=-4.72，-3.41，-2.31，respectively, all P<0.05). STING relative expression in patients with HBV DNA load≤104 IU/mL was 2.98, 3.76, and 3.97 folds of patients with HBV DNA load 104-105 IU/mL, 105-106 IU/mL, and＞106 IU/mL, respectively（P<0.05）. mRNA expressions of STING in CHB patients were positively correlated with that of IFNα and IFNβ mRNA (r=0.475, 0.503, respectively, both P<0.05). ConclusionThe expression of STING increased in patients with CHB, high expression of STING impacted the replication of HBV.

Abstract:

ObjectiveTo investigate epidemiological characteristics and incidence trend of gonorrhea in Nanshan District of Shenzhen, and provide a scientific basis for making control strategies.MethodsAn epidemiological analysis was performed on gonorrhea cases reported in Nanshan District of Shenzhen from January 2005 to December 2016, the autoregressive integrated moving average(ARIMA) model was used to predict the incidence trend. ResultsIn Nanshan District, a total of 9 590 cases of gonorrhea were reported from 2005 to 2016, the reported incidence ranged from 59.45/100,000 to 102.74/100,000, the average annual reported incidence was 78.79/100,000. 88.06% of cases mainly concentrated in 20-45 years old, 70.23% of occupations were mainly workers, official staff and houseworks. The monthly incidence of gonorrhea ranged 2.84/100,000-10.56/100,000. The ARIMA (1,1,1) model was constructed to predict the incidence of gonorrhea in Nanshan District of Shenzhen in 2017, it showed that the fluctuation of predicted incidence and actual incidence of gonorrhea in January-May 2017 was basically the same, the actual incidence was slightly higher than the predicted value, but it was in the 95% confidence interval of the predicted value. ConclusionThe epidemic situation of gonorrhea in this area is serious, ARIMA model can more accurately predict the trend of gonorrhea, the prediction results suggest that the incidence of gonorrhea is maintained at a high level, so effective measures based on epidemiological features are urgently needed to control gonorrhea.

Abstract:

ObjectiveTo explore the costeffectiveness of infection prevention and control of ventilatorassociated pneumonia (VAP). Methods12 hospitals in Jiangsu Province were chosen, a 1∶1 matched casecontrol multicenter study was adopted. The rate difference was calculated by Meta analysis. ResultsA total of 255 cases and controls were enrolled in this study. The study found that each VAP patient had to spend additional 103 799.00 yuan, stay in ICU for extra 11.72 days, and in hospital for extra 15.53 days. On the basis of the price index of different years, compared with 2014, 2015 saved 36 million yuan for patients. Prevention of one case of VAP in ICU could treat 0.76 more new patients. The hospital revenue was 24 464 560.5 yuan in 2015. The total direct economic benefits of hospitals and patients were 60 883 996.6 yuan. ConclusionPrevention and control of HAI is one of the medical ontology connotation, it can greatly reduce the economic burden of patients, save economic cost, create benefits and enhance the image for hospital, and achieve a triple win situation for "patientshospitalsociety".

Abstract:

ObjectiveTo understand the actual implementation of hand hygiene(HH)  of health care workers(HCWs), and provide evidence for improving HH management. MethodsHH performance appraisal began to implement in a hospital in 2016, at the same time, third party (healthcareassociated infection management professionals in other hospitals) was invited to carry out 4 times of anonymous survey on HH among HCWs in the hospital, change in HH compliance rate among HCWs was compared. ResultsHH compliance of HCWs surveyed by the third party was 60.68%, HH rates in the first half and second half year were 52.72% and 68.62% respectively, difference was statistically significant (P< 0.001). Compliance rate of HH in key departments (intensive care unit and neonatal department, 87.44%) was higher than surgical departments (64.71%) and internal medicine departments (53.74%), difference was statistically significant (both P<0.05). HH compliance rates of HCWs before and after contact with patients and after contact with the surrounding environment of patients were all low (53.59%, 58.07%, 43.97%, respectively). ConclusionHH surveyed by the third party can effectively reduce the Hawthorne effect during the observation process. HH performance appraisal can significantly improve the compliance of HH among HCWs.

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ObjectiveTo understand the status of surgical site infection(SSI) in department of cardiothoracic surgery, analyze the characteristics and influencing factors of SSI, and provide evidence for the prevention of SSI. MethodsA prospective monitoring method was used to investigate the medical records of patients undergoing cardiothoracic surgery in a hospital from January 1, 2014 to December 31, 2015, operation status and SSI of patients were monitored, risk factors for SSI were analyzed. ResultsA total of 1 953 surgery patients were investigated, 31 had SSI, incidence of SSI was 1.59%. Logistic regression analysis showed that length of hospital stay, malignant tumor, duration of indwelling drainage tube, and long length of operation were independent risk factors for SSI, OR(95%)CI were 8.48(1.12-63.98), 3.99(1.15-13.83), 2.54(1.07-6.02), and 2.11(1.01-4.39) respectively, (all P<0.05). ConclusionSSI prevention measures should be taken according to risk factors of SSI, so as to reduce the incidence of SSI.

Abstract:

ObjectiveTo understand detection results and difference in multidrugresistant organisms (MDROs) in intensive care unit (ICU) and nonICU. MethodsStrains isolated from clinical specimens of hospitalized patients in a hospital from January 2015 to December 2016 were analyzed, 6 kinds of MDROs were conducted targeted monitoring, isolation and antimicrobial resistance of 6 kinds of MDROs from ICU and nonICU patients were compared. ResultsA total of 1 013 strains of 6 kinds of MDROs were monitored, isolation rate was13.13%. Isolation rate of MDROs in ICU was higher than that of nonICU (24.60% vs 5.47%, P＜0.001）. Carbapenemresistant Acinetobacter baumannii(CRAB) was the main isolated MDROs, accounting for 69.40%；of different pathogenic organisms, isolation rate of CRAB was the highest (55.75%). The main MDROs detected in ICU and nonICU were both CRAB, accounting for 76.32% and 48.62% respectively； Of isolated pathogens, isolation rate of MDROs in ICU was higher than that of nonICU (47.95% vs 8.02%, P<0.001). Antimicrobial resistance rates of Escherichia coli isolated from ICU to ticarcillin/clavulanic acid, ceftriaxone, cefotaxime, cefepime, imipenem, meropenem, amikacin, and gentamicin were all higher than that of nonICU, resistant to piperacillin was lower than nonICU, difference was statistically significant (all P≤0.05); resistance rates of Klebsiella pneumoniae from ICU to common antimicrobial agents (except piperacillin ) were all higher than nonICU(all P<0.05). Resistance rates of Acinetobacter baumannii and Pseudomonas aeruginosa from ICU to common antimicrobial agents were all higher than nonICU (all P<0.05). Resistance rates of Staphylococcus aureus isolated from ICU to oxacillin, ciprofloxacin, tetracycline, and rifampicin were all higher than nonICU (all P<0.05), and resistance rates of Enterococcus faecium to quinupristin/dafoeleptin and tetracycline were both lower than nonICU (both P<0.05). ConclusionIsolation rate of MDROs in ICU is high, resistance rates to most antimicrobial agents are also higher than nonICU, monitoring on MDROs in ICU should be strengthened, and according prevention and control measures should be formulated.

Abstract:

ObjectiveTo construct a risk assessment tool framework for surgical wound infection(SWI). MethodsThe assessment system was constructed by referring to expert interviews, relevant domestic and foreign literatures, and the latest SWI guidelines. After two rounds of Delphi expert consultation, the assessment items were drawn up, selected and modified, and the initial scale was established. ResultsThe positive coefficients of two rounds of expert Delphi methods were 84% and 100% respectively; expert personal authority coefficient were both>75%, the all expert authority coefficient was 0.86; two rounds of Kendall’s W coefficients were 0.450 and 0.441 respectively (all P <0.05). The recommendations of two rounds of experts were 26 and 5 items respectively. The final assessment system indexes included 4 firstlevel indicators, 10 secondlevel indicators, and 27 thirdlevel indicators.ConclusionThe risk assessment tool framework for SWI is preliminarily established, which can provide a scientific basis for the effective evaluation of the risk of postoperative SWI.

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ObjectiveTo understand clinical distribution and antimicrobial resistance characteristics of Pseudomonas aeruginosa(P. aeruginosa) isolated from hospitalized patients, so as to provide reference for the empiric use of antimicrobial agents and control of healthcareassociated infection(HAI). MethodsClinical distribution and antimicrobial susceptibility testing results of P. aeruginosa isolated from patients in a hospital between 2012 and 2016 were analyzed retrospectively, statistical analysis were conducted based on different wards, specimen types and age groups. ResultsA total of 2 432 strains of P. aeruginosa were isolated from 2012 to 2016, most of which were isolated from intensive care unit(ICU) (n=727, 29.89%), the main specimen was sputum(n=2 064，84.87%）. Resistance rates of P. aeruginosa to other antimicrobial agents except piperacillin/tazobactam in each year from 2012 to 2016 were significantly different(all P<0.05). Resistance to piperacillin, ceftazidime, cefepime, imipenem, meropenem, levofloxacin, and ciprofloxacin decreased after peaked in 2014; resistance rates to amikacin, gentamicin, and tobramycin were all low, showing decreased trend year by year(all P<0.05). Except resistance rates to cefepime and tobramycin, resistance rates of P. aeruginosa from sputum specimen were all higher than other specimens(all P<0.05). Resistance rates of P. aeruginosa isolated from patients aged≥65 years to most antimicrobial agents were significantly higher than those isolated from patients aged＜65 years(all P<0.05). Except resistance rates to gentamicin and tobramycin, resistance rates of P. aeruginosa isolated from ICU were higher than those isolated from other departments, which were 7.71%-66.02%. Resistance rate of P. aeruginosa isolated from department of surgery were relatively low, which were 1.69%-11.86%. ConclusionClinical distribution of antimicrobial resistance of P. aeruginosa is obviously heterogeneity, empiric antimicrobial use and formulation of HAI monitoring measures should be based on the data of antimicrobial resistance in different wards, different infection sites, and different age.

Abstract:

ObjectiveTo explore the clinical significance of distribution of ABO blood group in patients with deep sternal wound infection(DSWI）after cardiac surgery. MethodsClinical data of 84 patients with DSWI after cardiac surgery in the department of cardiothoracic surgery in General Hospital of China Aviation of China Medical University in 2012-2014 were analyzed retrospectively, according to ABO blood group, patients were divided into 4 groups: A blood group, B blood group, AB blood group, and O blood group, according to whether the blood group was A group, they were divided into A blood group and nonA blood group. Distribution of ABO blood group in DSWI patients was analyzed, risk factors, clinical manifestations, and etiological characteristics of DSWI patients with different ABO blood groups were compared. ResultsAmong patients with DSWI, A blood group and nonA blood group were 33 cases (39.3%) and 51 cases（60.7%） respectively(B, O, and AB blood group were 16 cases［19.1%］, 29 cases ［34.5%］, and 6 cases ［7.1%］ respectively); the proportion of A blood group in DSWI patients was higher than that of the healthy population, but the difference was not statistically significant(P=0.055). Distribution of baseline characteristics and incidences of various clinical manifestations among DSWI patients of different blood groups were not statistically significant (all P>0.05). However, compared with nonA blood group or other ABO blood groups, DSWI patients with A blood group had higher incidence of elevated white blood cell count, difference was statistically significant (P<0.05), positive detection rate of grampositive bacteria in A blood group was also higher, difference was statistically significant (P<0.05). In addition, only 3 strains of Pseudomonas aeruginosa was detected only in B blood group, while gramnegative bacteria were not detected in AB blood group. ConclusionABO blood group may play a role in the pathogenesis of DSWI after cardiac surgery, which may be associated with a specific bacterial infection.

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ObjectiveTo understand the clinical features and prognosis of children with severe viral encephalitis(SVE), evaluate the related factors affecting prognosis. MethodsClinical data of 102 children with SVE in pediatric neurological ward and pediatric intensive care unit in Hunan Children’s Hospital between January 2014 and January 2016 were analyzed retrospectively. According to prognosis, children were divided into good prognosis group(n=24, children’s Glasgow outcome scale［CGOS］: 4-5) and poor prognosis group(n=78, CGOS:1-3), clinical data of two groups of children were compared, risk factors affecting the prognosis of SVE children were analyzed. ResultsIn good prognosis group, 15 cases were cured and 9 had mild sequelae; in poor prognosis group, 14 cases died， 25 had severe sequelae, and 39 had moderate sequelae. The duration of fever and length of hospital stay in good prognosis group were both shorter than poor prognosis group, difference was statistically significant (both P＜0.05). Multivariate unconditioned logistic regression analysis showed that adverse factors for prognosis of SVE were as follows: convulsive status, respiratory failure，longer fever period(>5 days), severely abnormal electroencephalogram(EEG), head magnetic resonance imaging (MRI) lesions involving more than two sites or lesions involving the infratentorial, and stress hyperglycemia, odds ratio(OR) were 13.468, 4.580, 2.378, 10.196, 3.012, and 6.316 respectively. ConclusionSVE is a serious threat to quality of children’s life, convulsive status, respiratory failure，longer fever period, severely abnormal EEG, head MRI lesions involving more than two sites or lesions involving the infratentorial, and stress hyperglycemia are risk factors for prognosis of SVE in children.

Abstract:

ObjectiveTo investigate the effect of business process reengineering(BPR) on improving multisectors’ participation in management of multidrugresistant organism(MDRO) infection, and provide methodological guidance for hospital multisectors’ collaborative management. MethodsRelated data about management and disposal of 672 cases of MDRO infection occurred from July 2015 to June 2017 were selected, 370 patients before BPR (from July 2015 to June 2016) were as control group, 302 patients after BPR (from July 2016 to June 2017) were as a trial group, BPR was used to improve the process of detection, report, cooperation, and disposal of MDROs in hospital, various quality evaluation indexes of healthcareassociated infection before and after BPR were compared. ResultsAfter the BPR was implemented, time of MDRO information transmitted from laboratory to clinical departments shortened from （240±30）minutes to （8±2）minutes; incidence of MDRO HAI decreased from 2.39‰ to 1.56‰ , isolation rate of MDROs decreased from 13.42% to 11.09%，differences were all significant(all P<0.05). Compliance rates and awareness rates of various MDRO prevention and control measures increased from 58.11%-71.89% to 84.11%-92.05%, usage rate of antimicrobial agents decreased from 53.18% to 48.45%, defined daily doses (DDDs) of antimicrobial use density decreased from 44.76 to 38.26, specimen submission rate before antimicrobial use increased from 46.68% to 53.62%. ConclusionBPR can enhance the cooperation between different departments, give full play to the complementary advantages of interdisciplinary, and improve the efficiency of HAI management.

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ObjectiveTo study the effect of chlorhexidine gluconate rubbing bathing on preventing multidrugresistant organism(MDRO) infection in patients in intensive care unit(ICU). Methods108 critically ill patients in a tertiary firstclass hospital between January and December 2016 were randomly divided into trial group and control group. Trial group adopted wet towel containing 2% chlorhexidine gluconate for bathing, control group adopted water for bathing. Bacteriostasis rate, incidence of healthcareassociated infection(HAI), occurrence of MDRO infection, and adverse reaction between two groups of patients after rubbing bathing were compared. ResultsThere was no significant difference in the bacteriostasis rate within 2 hours between two groups（P>0.05）, bacteriostasis rates of trial group after 4, 8, and 24 hours of bathing were significantly higher than control group（P<0.001）. Incidences of HAI in trial group and control group were 44.44%（24/54）and 66.67%（36/54）respectively（P＜0.05）； incidences of MDRO infection in trial group and control group were 20.37%（11/54）and 40.74%（22/54）respectively（P＜0.05）. The main infection sites in trial group and control group were both lower respiratory tract, accounting for 87.50% and 72.22% respectively; 8 cases (33.33%) in trial group and 11 (30.55%) in control group had ventilatorassociated pneumonia (VAP). 11 strains of MDROs in trial group and 22 in control group were isolated, both were mainly carbapenemresistant Acinetobacter baumannii (CRAB). There was no adverse reaction after the bathing in both groups. ConclusionApplication of chlorhexidine gluconate bathing can effectively reduce the incidence of HAI and MDRO infection in ICU patients.

Abstract:

ObjectiveTo analyze the change in isolation rates of multidrugresistant organisms (MDROs) before and after adopting plandocheckact (PDCA) cycle method for management of MDROs. MethodsBacterial culture specimen submission and isolation of MDROs in a tertiary firstclass hospital before the implementation of PDCA cycle (January 2013December 2014) and after implementation of PDCA cycle (January 2015December 2016) were collected and analyzed. ResultsA total of 14 889 specimens were sent for detection before the implementation of PDCA cycle, 6 345 strains were isolated, 650 of which were MDROs, isolation rate of MDROs was 10.24%; after the implementation of PDCA cycle, 17 856 specimens were sent for detection, 7 568 strains were isolated, 476 were MDROs, isolation rate of MDROs was 6.29%; difference in MDRO detection rate before and after the implementation of PDCA was statistically significant （χ2=72.567，P＜0.001）. After CochranArmitage trend test, the isolation rates of MDROs in 20132016 showed a decreased trend (Z=-7.8856). The amount and cost of hand hygiene products have increased. ConclusionBy carrying out PDCA cycle for MDROs management, the isolation rate of MDROs in hospital is reduced. PDCA cycle management method can effectively promote the continuous quality improvement of hospital MDROs management.

Abstract:

ObjectiveTo investigate the cleanliness status of personal digital assistant (PDA) surfaces, and observe the effect of disposable antiseptic wipes on the cleaning and disinfection of PDA surface. MethodsFrom January to March 2016, 83 daily used handheld PDA in 50 clinical wards of a hospital were as control group, 83 PDA disinfected by disposable antiseptic wipes(CaviWipes) and used in the same environment of the ward at the same time were selected as the intervention group, cleanliness status of PDA surfaces of two groups were detected by adenosine triphosphate (ATP) bioluminescence assay. ResultsTaken a cutoff value≤100 RLU／100 cm2 as qualified standard of cleanliness, none of PDA in control group was qualified with ATP bioluminescence reading ranged from 189 to 3 379 RLU; after disinfection with CaviWipes, the qualified rate of intervention group was 90.4%(n=75), ATP detection value of PDA surface in all departments were significantly lower than control group(median: ［18-28］ RLU vs ［290-339］ RLU, all P＜0.05）. ConclusionMicrobial contamination on PDA used in hospital wards is common, antiseptic wipes containing quaternary ammonium salt can be used for cleaning and disinfecting surface of PDA.

Abstract:

ObjectiveTo evaluate disinfection efficacy of slightly acidic hypochlorous water (SAHW) on object surfaces of hemodialysis room. Methods30 dialysis units in the hemodialysis room were divided into two groups(trichloroisocyanuric acid group and SAHW group) by random number table method, 15 dialysis units in each group. Trichloroisocyanuric acid group disinfected object surface of each hemodialysis unit with trichloroisocyanuric acid containing 500 mg/L available chlorine, and SAHW group disinfected with SAHW. The colony counts on object surface after 4 hour disinfection were detected, the qualified status and killing of multidrugresistant organisms(MDROs) between two disinfection methods were compared. ResultsAfter bedrails, screens of dialysis machine, and knobs of dialysis machine were disinfected by trichloroisocyanuric acid containing 500 mg/L available chlorine and SAHW respectively, the qualified rates of trichloroisocyanuric acid group were 90.00%,80.00%, and 90.00% respectively, SAHW group were 100.00%, 96.67%, and 100.00% respectively, difference was not significant between two disinfection methods(both P>0.05). SAHW disinfection testing showed that the killing rates of SAHW to four MDROs were both 100%. ConclusionDisinfection efficacy of SAHW is the same as that of trichloroisocyanuric acid containing 500 mg/L available chlorine, and has high killing effect on the common MDROs in the hemodialysis room.

Abstract:

ObjectiveTo improve the qualified rate of cleaning of loaner orthopedic surgery instruments by application of quality control circle(QCC). MethodsQCC activity was carried out in a hospital from May to October 2016, onsite assessment of cleaning quality was performed by two circle members, causes of unqualified cleaning result of loaner orthopedic surgery instruments were recorded, the qualified result of loaner orthopedic surgery instruments before QCC activity (MayJune 2016) and after QCC activity (SeptemberOctober 2016) was compared. ResultsBefore QCC activity, there were 1 667 packages of loaner instruments, 1 415 were qualified for cleaning, qualified rate was 84.88%; after activity, there were 1 673 packages of loaner instruments, 1 655 were qualified for cleaning, qualified rate was 98.92%, difference was statistically significant between two groups (P<0.01), qualified rate increased to 14.04%, target achievement rate was 116%.ConclusionApplication of the scientific tool of QCC can improve the qualified rate of cleaning of loaner orthopedic surgery instruments.

Abstract:

Infection is an important cause of higher mortality in patients with hematological diseases than healthy people, and fever is often the only indication of the disease. Clostridium perfringens(C. perfringens) is a grampositive anaerobic bacillus of the Clostridium genus, it belongs to the normal flora of the intestinal tract and is not pathogenic in normal condition. However, when intestinal flora is imbalanced due to low hypoimmunity of human body or influenced by such factors as diet, medicine, environment and other factors, it can enter the blood and cause bacteremia. At present, it has never been reported that bacteremia was caused by C. perfringens in patients with malignant hematological diseases accompanied by neutropenia, this article reported the diagnosis and treatment of C. perfringens bloodstream in one patient with malignant hematopathy, so as to provide basis for diagnosis and treatment of the disease. 

Abstract:

口腔综合治疗台水路（dental unit waterlines，DUWLs）是口腔综合治疗台（dental chair units，DCUs）的重要组成部分，为口腔诊疗提供水源保障［1］。但研究发现其常存在严重污染［24］，污染原因主要包括防回吸装置失效、供水水源污染、管道中生物膜定植等。DUWLs中的细菌可随着水流进入患者口腔内，也可形成气溶胶污染诊室环境［5］，导致患者及医护人员发生医源性感染，是口腔诊疗过程中的感染控制重点之一。对此，目前国内外相关干预控制措施较多，主要分为物理措施和化学措施，本文对其进行综述，旨在为今后开展相关感染控制工作提供借鉴。