ObjectiveTo evaluate the influence of comprehensive intervention model on reducing surgical site infection(SSI) in patients with caesarean section. MethodsPatients were divided into two groups: control group included 500 patients who were undergone emergency caesarean in JanuaryDecember 2011; intervention group included 501 patients who were undergone emergency caesarean section in JanuaryDecember 2012, patients were matched in a 1∶1 ratio. SSI rates between two groups were compared, the average hospitalization days and hospitalization expense between infected patients and noninfected patients after comprehensive intervention were compared.ResultsAfter intervention, the rate of correct surgical handwashing increased from 54.55% before intervention to 90.48%; pathogenic detection rate increased from 18.42% to 89.66%; timely reporting rate of SSI increased from 16.67% to 80.00% (all P<0.05); SSI in intervention and control group was 1.00% (5/501) and 3.60% (18/500) respectively (χ2=8.40, P<0.01).The average length of hospital stay of 23 SSI patients was significantly longer than 978 noninfected patients (［16.61±4.81) d vs ［6.09±1.37］ d, t=32.60, P<0.01); hospitalization expense in SSI patients was significantly higher than noninfected patients (［7 042.43±1 229.57］ yuan vs ［5 085.80±737.14］ yuan, t=12.34, P<0.01).ConclusionComprehensive intervention can effectively reduce SSI following caesarean section and warn the outbreak and epidemic of HAI.